Description Usage Supplement Facts B Complex #12 supports energy production and healthy neurological function.* Unlike many multi-B vitamins, it contains the active forms of eight water-soluble B vitamins.* B-Complex #12 offers a complete vitamin B complex, with added vitamin B-12 and folate. Supplementing with the active forms of the B vitamins is extremely important to everyone, especially individuals who might not be able to convert non-active B vitamins to their active forms in the liver because of compromised liver function, poorly functioning enzymes, digestive disorders, or increasing age.* Vitamin B12 and folate are necessary for normal red blood cell formation, tissue and cellular repair, normal methylation and homocysteine metabolism, and DNA synthesis.* Thorne's B-Complex #12 supplies the two active forms of vitamin B12 – adenosylcobalamin and methylcobalamin – as well as the two active forms of folate – folinic acid and 5-MTHF. The other bioactive forms of the B vitamins in each capsule ensures you will get the most bioavailable vitamin B complex available.* B-Complex #12 is not derived from yeast. Most of the B vitamins, with the exception of vitamin B12, are not stored in the body; consequently, they must be acquired daily from the diet in order to maintain optimal health.* Vitamin B12 deficiency can be manifest with varying degrees of mental changes, such as confusion and irritability.* Certain prescription medications (for seizures, diabetes, arthritis, and cancer) can cause a deficiency of these important vitamins. The incidence of vitamin B12 and/or folate deficiency is high among the elderly. Pregnant women require an increased amount of folate for proper fetal development.* A woman who has a folate deficiency prior to pregnancy can expect that deficiency to be intensified during pregnancy. B Complex #12 includes eight water-soluble B vitamins: thiamin (vitamin B1); riboflavin/riboflavin 5'-phosphate (vitamin B2); niacinamide (vitamin B3); pantothenic acid (vitamin B5); pyridoxine/pyridoxal 5'-phosphate (vitamin B6); methyl- and adenosylcobalamin (vitamin B12); folinic acid and 5-MTHF (folate); and biotin; plus choline. Although each B vitamin is chemically distinct, they often work synergistically in various biochemical functions throughout the body – from cellular energy production, to healthy red blood cell formation, to healthy neurological function.* A nutritional supplement that contains these active cofactors has enhanced bioavailability, ensuring the body gets the nutrients it needs.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Suggested Use Take 1 capsule one to three times daily or as recommended by your health professional. If pregnant, consult your health-care practitioner before using this product. Doses of vitamin B6 above 200 mg may inhibit breast milk production. Folinic acid and 5-methyl-tetrahydrofolate supplementation is not recommended concurrently with methotrexate cancer therapy, as they can interfere with methotrexate's anti-neoplastic activity; however, these folate sources have not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate. INTERACTIONS/CONTRAINDICATIONS: Folinic acid and 5-methyl-tetrahydrofolate supplementation is not recommended concurrently with methotrexate cancer therapy, as they can interfere with methotrexate's anti-neoplastic activity; however, these folate sources have not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate. Tamper resistant. Use only if safety seal is intact. Keep out of the reach of children. Store sealed in a cool‚ dry area. SUPPLEMENT FACTS Serving size: 1 capsule Servings per container: 60 Ingredients Amount %DV* Thiamin (as Thiamin HCI) 40 mg 3,333% Riboflavin (25mg as Riboflavin and 3.6mg as Riboflavin 5'-Phosphate Sodium) 28.6 mg 2,200% Niacin (as Niacinamide) 80 mg 500% Vitamin B6 (20 mg as Pyridoxine HCl and 3.4 mg as Pyridoxal 5'-Phosphate) 23.4 mg 1‚376% Folate (400mcg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic acid‚ glucosamine salt) 668 mcg DFE 167% Vitamin B12 (as Methylcobalamin) 600 mcg 25‚000% Biotin 80 mcg 267% Pantothenic Acid (as Calcium Pantothenate) 45 mg 900% Choline Citrate 14 mg 3% Other Ingredients: Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Calcium Laurate, Silicon Dioxide * % Daily Values are based on a 2,000 calorie diet.† Daily Value not established This product uses Gnosis S.p.A.'s L-5-Methyltetra-hydrofolic Acid, Glucosamine Salt (Quatrefolic®). Quatrefolic is a registered trademark of Gnosis S.p.A.