Description Usage Supplement Facts Many individuals don't get sufficient 5-MTHF (L-5-Methyltetrahydrofolate), the active form of folic acid, because they have intestinal or liver dysfunction, or because they are among the three out of five Americans whose genetic makeup makes it difficult to convert folic acid into active 5-MTHF.* A deficiency of folic acid has been linked to low-birth-weight infants and neural tube defects, which is why the Centers for Disease Control recommends folic acid supplementation for all women of childbearing age. Since 5-MTHF also contributes to the production of serotonin, melatonin, dopamine, epinephrine, and norepinephrine, supplementation supports healthy mood.* (Note: 1 mg of 5-MTHF is recommended for fetal support during pregnancy; the 15 mg option is recommended only when directed by a health-care practitioner.*) *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Suggested Use Adults: Take 1 capsule daily. This product is intended for use under the guidance of a health-care practitioner. 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity. If you are pregnant, nursing, or undergoing treatment for a medical condition, please consult your healthcare professional before using this product. Store in a cool, dry place and tightly capped. Keep out of the reach of children. Tamper resistant package, do not use if outer seal is missing. SUPPLEMENT FACTS Serving size: 1 capsuleServings per container: 30 Ingredients Amount %DV Folate (15 mg as L-5-Methyltetrahydrofolate**) 25 mg DFE 6,250% * % Daily Values are based on a 2,000 calorie diet.† Daily Value not established. Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide. **This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-S®). Extrafolate-S is a registered trademark of Gnosis S.p.A.